당뇨 유발 쥐의 망막에서 효소조직화학염색에 의한 뮐러세포의 형태학적 연구

• 영문명: The Morphological Study of Muller Cells with Enzyme Histochemical Staining in Retina of Induced Diabetic Rats
• 발행기관: 대한안과학회
• 저자명: 문수정 김인철 이동욱 신화 조남천,Su Joung Mun, M.D., In Cheol Kim, M.D., Dong Wook Lee, M.D., Hua Xin, Nam Chun Cho, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume48,number5, 708~714쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.05.31

영문 초록

Purpose: To evaluate the morphological changes in Muller cells of an induced diabetic rat model with carbonic anhydrase histochemical staining. Methods: Retinae of three normal rats and four streptozotocin-induced diabetic rats were used. The morphological changes in the Muller cells of these retinae were observed using enzyme histochemical staining. Results: The numbers of positive staining Muller cells in diabetic rats retinae were significantly lower than those of the normal rats. In addition, the shape of the Muller cell bodies in the streptozotocin-induced diabetic rat model’s retina changed from polygonal to abnormally flat. Furthermore, the staining of the Muller cells’ segment in the outer nuclear layer of the diabetic rat’s retinae were weaker, and some Muller cell segments were not stained at all. Conclusions: The numbers of Muller cells in diabetic rats’ retinae were significantly lower than those of the normal rats. In addition, the features of Muller cell bodies of the diabetic rats were changed morphologically.

키워드

Carboic anhydrase, Diabetic rats’ retina, Enzyme histochemistry, Muller cell