섬유주절제술 후 여과포형성에 실패한 환자에서 마이토마이신씨를 이용한 주사침복원술의 효과

• 영문명: Needle Revision with and without Mitomycin C for the Teatment of Failed Filtering Blebs after Trabeculectomy
• 발행기관: 대한안과학회
• 저자명: 노인호 형성민,In Ho Roh, M.D., Sung Min Hyung, M.D., Ph.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number7, 1087~1092쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.07.31

영문 초록

Purpose: To evaluate the effects of needle revision (NR) with and without mitomycin C (MMC) for failed filtering blebs after trabeculectomy, and to identify risk factors for failure. Methods: Thirty-one eyes whose intraocular pressure (IOP) did not decrease after cutting of scleral flap sutures were recruited. NR was performed with a 26-gauge needle under a slit-lamp. Immediately following NR, 15 eyes received subconjunctival injection of 0.002 mg (0.02 mg/ml) MMC at the adjacent conjunctiva. Results: First NR was done at 1.3±1.2 months (range, 0.2~6.5 months) after trabeculectomy, and a mean of 1.6±1.6 NRs per patient were done. The follow-up period was 24.4±20.4 months (range, 6.0~87.4 months) after the last NR. Pre-NR mean IOP was 27.9±11.6 mm Hg and post-NR final IOP was 18.8±13.0 mm Hg (p=0.005). The success rate, defined as IOP ≤18 mm Hg with or without medication, was 80.3% (25 eyes of 31 eyes). The success rate was higher in the group receiving NR with adjunctive MMC (100%) than in the group receiving NR without MMC (62.5%) (p=0.018). Patients who underwent trabeculectomy without adjunctive MMC and those who had pre-NR IOP >25 mm Hg showed a higher failure rate, though with no statistical significance (p=0.141 and p=0.173, respectively). Conclusions: NR followed by subconjunctival injection of MMC is an effective and safe method for the treatment of the failed filtering blebs after trabeculectomy. Trabeculectomy without adjunctive MMC and pre-NR IOP higher than 25 mmHg were risk factors for failure of NR.

키워드

Filtering bleb, Mitomycin C, Needle revision