당뇨황반부종의 치료에서 유리체 절제술의 효과와 유리체강 내 트리암시놀론 주입술과의 비교

• 영문명: Effects of Pars Plana Vitrectomy Comparing with Intravitreal Triamcinolone Acetonide Injection in Diabetic Macular Edema
• 발행기관: 대한안과학회
• 저자명: 김용민 김성수 이성철 권오웅 고형준,Yong Min Kim, M.D., Sung Soo Kim, M.D., Sung Chul Lee, M.D., Oh Woong Kwon, M.D., Hyung Jun Koh, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number7, 1072~1079쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.07.31

영문 초록

Purpose: The purpose of this study is to evaluate the benefit of pars plana vitrectomy (PPV) and removal of the internal limiting membrane (ILM) in diabetic macular edema, and to compare the effects of PPV and removal of ILM with intravitreal triamcinolone acetonide injection. Methods: Fifteen eyes of 14 patients on whom PPV and removal of the ILM (group A) were performed and 14 eyes of 14 patients who received single intravitreal triamcinolone acetonide injection (group B) for diabetic macular edema over six months were included in this study. The main outcome measures were macular thickness, as measured by optical coherence tomography and visual acuity at 1, 3, and 6 months postoperatively. Results: The mean preoperative visual acuity was 0.06±0.05 and macular thickness 516.01±120.29 ?m in group A. At 1 month postoperatively, this group showed no significant improvement of visual acuity. However, there was significant improvement at 3 and 6 months postoperatively. Macular thickness also decreased significantly at 1, 3, and 6 months postoperatively. In group B, the mean preoperative visual acuity was 0.10±0.08 and macular thickness was 548.82±116.44 ?m. At 1 and 3 months postoperatively, significant improvement of visual acuity was noted in this group. However, there was no significant difference at 6 months postoperatively. Macular thickness also decreased significantly at 1, 3, and 6 month postoperatively. Between two groups, visual acuity and macular thickness improved in Group B at 1 month postoperatively but at 6 months, visual acuity improved in Group A and there was no significant difference of macular thickness between the two groups. Conclusions: PPV and removal of the ILM are good therapeutic options for diabetic macular edema to improve visual acuity and macular thickness. These also offer more long term efficacy than intravitreal tiamcinolone acetonide injection.

키워드

Diabetic macular edema, Internal limiting membrane, Pars plana vitrectomy, Triamcinolone acetonide