가토에서 트리암시놀론이 증식유리체망막병증과 간세포 성장인자의 농도에 미치는 영향

• 영문명: Effect of Triamcinolone Acetonide on Proliferative Vitreoretinopathy and Hepatocyte Growth Factor in a Rabbit Model
• 발행기관: 대한안과학회
• 저자명: 박영훈 이원기 김경락 김현승 이영춘 정성근,Young Hoon Park, M.D., Won Ki Lee, M.D., Kyung Rak Kim, M.D., Hyun Seung Kim, M.D., Young Chun Lee, M.D., Sung Kun Chung, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number2, 297~304쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.02.28

영문 초록

Purpose: To investigate the intravitreal level change of hepatocyte growth factor (HGF) in a rabbit model of proliferative vitreoretinopathy (PVR) and the effect of triamcinolone on PVR and intravitreal HGF concentration. Methods: Experimental PVR was induced in 21 New Zealand white rabbits by performing a scleral laceration, followed by repair and intravitreal injection of 0.1 ml of autologous blood. Seven eyes (group A) were injected with a high -dose of triamcinolone (5 mg), 7 eyes (group B) with a low -dose of triamcinolone (1 mg), and 7 control eyes (group C) with only balanced salts solution (BSS), respectively. Intravitreal HGF levels were measured by ELISA test taken at 0, 3, 7, 14, 21, and 28 days after PVR induction. PVR grade was determined by serial indirect ophthalmoscopic examination at different time points mentioned. Results: Elevated HGF levels were found in the vitreous peaking at 7 days after PVR -inducton in all 3 groups. The differences in HGF levels of treated groups A and B, and the control group C were statistically significant (p<0.001). The differences of PVR grades among the 3 groups were not statistically significant. However, gross and microscopic examinations of the control group C showed that proliferations and morphologic changes of retinal pigment epithelial cells were more prominent than in the treated groups. Conclusions: The intravitreal level of HGF varied with time in the rabbit PVR model. Also, our results suggest that intravitreal triamcinolone suppresses the expression of intravitreal HGF in the rabbit PVR model.

키워드

Hepatocyte growth factor, Proliferative vitreoretinopathy, Triamcinolone