백내장 수정체 상피세포의 변형성장인자 발현

• 영문명: The Expression of TGF-β Isoform mRNA in the Cataract Lens Epithelial Cell
• 발행기관: 대한안과학회
• 저자명: 김도형 양재욱 박세광 김성두 허준 윤일한 최인학,Do-Hyung Kim, M.D., Jae-Wook Yang, M.D., Seh-Kwang Park, M.D., Sung-Doo Kim, M.D., Jun Hur, M.D., Ill-Han Yoon, M.D., In-Hak Choi, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number8, 1393~1400쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.08.31

영문 초록

Purpose: Transforming growth factor (TGF)-β is recognized as being associated with cataractogenesis. We quantitated the mRNA expression of TGF-β isoforms in cataractous crystalline lens to determine the effect of the isoforms on cataractogenesis. Methods: With lens epithelial cells from thirty eyes in thirty patients, the mRNA expressions of TGF-β1, β2 and β3 were quantitated by real-time SYBR Green polymerase chain reaction and the results were compared according to cataract type and presence of diabetes mellitus. Results: Each isoform mRNA of TGF-β was expressed: TGF-β3 in all 30 eyes, TGF-β1 in 29 eyes (96.7%), with the exception being one diabetic senile cataract, and TGF-β2 in 9 eyes. The amount of TGF-β1 mRNA expression was significantly lower in the diabetic cataracts than in the non-diabetic cataracts (P=0.056). Conclusions: TGF-β was associated with cataractogenesis. It is significant that the expression of TGF-β2 mRNA was decreased in all cataracts. The decrease of TGF-β1 mRNA expression was more meaningful in the diabetic cataracts than in the non-diabetic cataracts.

키워드

Cataract lens epithelial cell, Senile cataract, TGF-β isoform Mrna