유두상 갑상선 미세암의 임상 병리학적 예후 인자에 관한 후향적 분석

• 영문명: Clinical Characteristics and Prognostic Factors of Papillary Microcarcinoma: Results from Retrospective Analysis of 176 Patients
• 발행기관: 대한내분비외과학회
• 저자명: 송대근 최영진 강윤중 박혜원 박주승 조병선 김창남 이민구 Dae Keun Song M.D. Young Jin Choi M.D. Yoon Jung Kang M.D. Hye Won Park M.D. Joo Seung Park M.D. Byung Sun Joe M.D. Chang Nam Kim M.D. and Min Koo Lee M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』9권2호, 79~84쪽, 전체 6쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2009.06.30

영문 초록

Purpose: The clinical importance and characteristics of papillary thyroid microcarcinoma (PTC) are still under debate, and the criteria for appropriate treatment have yet to be established. In this study, we attempted to examine the appropriate extent of surgery and the desirability of prophylactic lymph node (LN) dissection through identification of factors influencing LN metastasis and capsular invasions. Methods: We reviewed the medical records of 176 consecutive biopsy-proven PTC patients. The clinical and pathological prognostic factors including LN metastasis and capsular invasion were analyzed. Chi-square test and independent sample T-test were used for statistical analysis. Results: The median age of patients was 47-years-of-age (range 23∼80 years). Among 108 patients who underwent central LN dissection, 38 (35.8%) patients showed LN metastasis. Univariate analysis revealed that male patients showed significantly more LN metastasis than female patients and lymphovascular invasion significantly affected LN metastasis. Twenty-eight (14.8%) patients showed capsular invasion. Tumor size, especially tumors ≥5 mm in diameter, and tumor multiplicity were significantly associated with capsular Invasion. Lymphatic or venous invasion also affected the occurrence of capsular invasion. Conclusion: Patients who are male, have a tumor larger than 5 mm in diameter, or multiple tumors are more likely to develop LN metastasis or capsular invasions. These factors could help us to decide the extent of thyroidectomy and to select patients who need prophylactic LN dissection. (Korean J Endocrine Surg 2009;9:79-84)

키워드

유두상 갑상선미세암, 림프절 전이, 피막침범,Papillary thyroid microcarcinoma, Lymph node metastasis, Capsular invasion