갑상선 유두암의 여포성 변이; 임상병리학적 특징

• 영문명: Follicular Variant of Papillary Thyroid Carcinoma; Clinicopathologic Features
• 발행기관: 대한내분비외과학회
• 저자명: 김신영 채병주 정소령¹ 정찬권² 임동준³ 송병주 김정수 김승남 배자성 Shinn Young Kim M.D. Byung Joo Chae M.D. So Ryeong Jung M.D.¹ Chan Kwon Jung M.D.² Dong Jun Lim M.D.³ Byung Joo Song M.D. Jeong Soo Kim M.D. Seung Nam Kim M.D. and Ja Seong Bae M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』9권2호, 65~68쪽, 전체 4쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2009.06.30

영문 초록

Purpose: The follicular variant of papillary thyroid carcinoma (FVPTC) is the most common subtype of papillary thyroid carcinoma (PTC). However, the clinicopathologic features of patients with FVPTC with those of patients with pure PTC is ill-understood. This study evaluated differences in clinicopathologic features of FVPTC compared with pure PTC. Methods: All patients with FVPTC or pure PTC diagnosed between January 2006 and August 2008 at our institution were retrospectively reviewed. The two groups were compared in terms of clinocopathological features. Results: Of 417 patients, 370 had PTC, and 47 patients had FVPTC. The meanage was 47.1 years. There was no differencein age and sex ratio between the two groups, and both groups were similar in terms of tumor size, presence of multifocality, thyroid capsular invasion, and extrathyroidal extension. However, FVPTC patients had significantly lower lymph node metastases (P=0.015) and significantly higher tumor encapsulation (P=0.031). Galectin-3 expression was decreased in FVPTC (P=0.012). Conclusion: The clinicopathologic features of FVPTC are more favorable. The possibility of FVPTC could be considered when thyroid nodules with negative galectin-3 expression have suspicious or malignant fine needle aspiration biopsy. (Korean J Endocrine Surg 2009;9:65-68)

키워드

갑상선 유두암, 순수 갑상선 유두암, 여포성 변이,Papillary thyroid cancer, Pure papillary thyroid cancer, Follicular variant