식물 유래 당단백질의 당질 구조 분석

• 영문명: Structural Analysis of Oligosaccharides of a Plant Glycoprotein
• 발행기관: 대한약학회
• 저자명: 배재우(Jae Woo Bae) 박병태(Byung Tae Park) 윤두천(Doo Chun Yoon) 김주영(Joo Young Kim) 황혜성(Hye Sung Hwang) 박현주(Hyun Joo Park) 나종천(Jong Chun Na) 김하형(HaHyung Kim)
• 간행물 정보: 『약학회지』제54권 제6호 (2010년), 449~454쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.12.31

영문 초록

The glycosylation of glycoproteins from mammalian or plants can affect their efficacy, stability, solubility, and half-life. In the present study, we investigated plant glycosylation and their relative intensity (%) in a plant carbohydratebinding protein with the hemagglutination and antiproliferative activities. The hemagglutination activity on the deglycosylated protein was decreased as a 16-fold than that of intact glycoprotein. Using the HPLC with fluorescence detector and mass spectrometer, the major eight bi- or triantennary oligosaccharides containing xylose, fucose, mannose, galactose, and N-acetylglucosamine were identified and structurally characterized. The present results indicate that the oligosaccharides on this plant glycoprotein is necessary for their own property.

키워드

plant glycoprotein oligosaccharide structure