생쥐 피질세포배양에서 Free Radical 유발 신경손상에 대한 손바닥선인장 및 삼백초의 보호효과

• 영문명: Protective Effects of Opuntia Ficus-Indica and Saururus Chinensis on Free Radical-Induced Neuronal Injury in Mouse Cortical Cell Cultures
• 발행기관: 대한약학회
• 저자명: 위명복(Myung Bok Wie)
• 간행물 정보: 『약학회지』제44권 제6호 (2000년), 613~619쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.12.30

영문 초록

The author examined whether the methanol extracts of Opuntia ficus-indica fruit and Saururus chinensis have the inhibitory action on xanthine/xanthine oxidase (X/XO)-, FeCl2/ascorbic acid- and arachidonic acid-induced neurotoxicity in mouse cortical cell cultures. The methanol extracts (10mcg/ml~1mg/ml) of Opuntia ficus-indica and Saururus chinensis were exhibited 53-89% and 48-100% inhibitory action on X/XO-induced neurotoxicity, respectively. At the range of same concentration, both extracts also attenuated the FeCl2/ascorbic acid-induced neurotoxicity by 35-100% and 15-98%, respectively. In arachidoiic acid neurotoxicity, the methanol extracts (1mg/ml) of Opuntia ficus-indica and Saururus chinensis reduced neuronal injury by 22% and 38%, respectively. These results suggest that Opuntia ficus-indica fruit and Saururus chinensis may contribute the neuroprotection in certain free radical-mediated neuronal injury.

키워드

Opuntia ficus-indica Saururus chinensis neuroprotection superoxide anion radical hydroxyl radical arachidonic acid mouse cortical cultures.