재조합 인간상피세포 성장인자(rhEGF, DWP401)의 배, 태자 발달 독성 연구

• 영문명: Embryo and Fetal Developmental Toxicity Study on Recombinant Human Epidermal Growth Factor (rhEGF) in Rats
• 발행기관: 대한약학회
• 저자명: 박귀례(Kui Le Park) 한순영(Soon Young Han) 신재호(Jae Ho Shin) 이유미(Yoo Mie Lee) 박희정(Hee Jung Park) 장성재(Seung Jae Jang)
• 간행물 정보: 『약학회지』제42권 제5호 (1998년), 534~539쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.10.31

영문 초록

Effect of recombinant human epidermal growth factor (rhEGF, DWP401) on fetal external, visceral and skeletal malformation during organogenesis was examined. Pregnant Sprauge-Dawley rats were administered with 0.2, 1 and 5mg/kg/day subcutaneously on gestation day 6 through 16. Dams were sacrified at 20th day of gestation. Materal body weight, food consumption and clinical observation were not changed. Significant dose-dependent increase of relative and absolute liver weight were observed in the treatment group, whereas other organ weights were not changed. Placental weight of 1 and 5mg/kg/day group and number of resorption in 5mg/kg/day treatment group were significantly increased. External and visceral malformation of fetuses were not observed with treatment. However, skeletal variations(increase of asymmetry sternebrae, decrease of dumb-bell and asymmetry sternbrae at 5mg/kg/day, and fused stemebrae at 5mg/kg/day) were observed. These results showed that rhEGF (DWP401) may not have embryo and/or fetal developmental toxicity effect in rats.

키워드

rhEGF(DWP401) embryo and fetal developmental toxicity rats.