리포포리사카라이드의 세포성 면역반응에 미치는 스와인소닌의 영향

• 영문명: Effects of Swainsonine on the Cell-mediated Immune Responses of Lipopolysaccharide
• 발행기관: 대한약학회
• 저자명: 채병숙(Byeong Suk Chae) 안영근(Young Keun Ahn) 김정훈(Joung Hoon Kim)
• 간행물 정보: 『약학회지』제42권 제1호 (1998년), 75~81쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.01.31

영문 초록

Effects of swainsonine (SW: 8alpha, beta-indolizidine-1alpha, 2alpha, 8beta-triol from Locoweed) on the cellular and nonspecific immune responses of lipopolysaccharide (LPS) were studied in ICR mice. Mice were divided into 4 groups (10mice/group), and LPS was given to each mouse 1 hr after i.p. injection with 3.7mg/kg of SW by i.p. injection twice a week for 14 days at a dose of 2mg/kg. Immune responses of the delayed-type hypersensitivity response (DTH) to sheep red blood cells (s-RBC), phagocytic activity and natural killer (NK) cell activity were evaluated. LPS treatment didn`t affect NK cell activity, phagocytic activity, DTH to s-RBC compared with those in controls, and phagocytic activity of sareoma 180 tumor bearing mice. However, circulating leukocytes were significantly decreased. Combinaton of LPS and SW increased circulating leukocytes significantly compared vath that in LPS alone, and DTH to s-RBC, NK cell activity and phagocytic activities of normal and sarcoma tumor bearing mice were not affected. These findings indicate that SW didn`t affected the cellular immune responses suppressed by LPS but significantly increased circulating leukocytes.

키워드

Lipopolysaccharide swainsonine delayed-type hypersensitivity phagocytic activity NK cell activity circulating leukocyte.