신장장해 가토에서 Furosemide의 약물동태

• 영문명: Pharmacokinetics of Furosemide in Rabbits with Renal Failure
• 발행기관: 대한약학회
• 저자명: 최준식(Jun Shik Choi) 최토마(Tou Ma Choi) 이진환(Jin Hwan Lee) 범진필(Jin Pil Burm)
• 간행물 정보: 『약학회지』제34권 제6호 (1990년), 401~406쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.12.28

영문 초록

The Pharmacokinetics of furosemide (5mg/kg iv) was investigated in rabbits with folate (75mg/kg, 150mg/kg 300mg/mcg, iv) induced renal failure. The plasma concentration was increased and urinary excretion was decreased significantly compared with those of normal rabbits. alpha, beta and K12, K21, K10 were decreased, t1/2 and AUC were increased significantly. Correlation of serum creatinine concentration and AUC, renal clearance have linear relationship respectively. In short, dosage regimen of furosemide is considered to be adjusted in the dose size and the dosing interval by degree of serum creatinine concentration.

키워드

Pharmacokinetics furosemide Renal failure Creatinine