1-beta-D-Arabinofuranosylcytos의 Prodrug 연구 AraC-5'-Alkylthioacetates 합성 및 그들의 물리.화학적 성질과 항암작용 시험

• 영문명: Study on Prodrugs of 1-beta-D-Arabinofuranosylcytosine Preparation of araC-5''-Alkylthioacetates and Evaluation of their Physical-chemical Properties and Antitumor Activities.
• 발행기관: 대한약학회
• 저자명: 이희주(Hee Joo Lee) 김태련(Tae Ryun Kim)
• 간행물 정보: 『약학회지』제32권 제5호 (1988년), 334~339쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.08.29

영문 초록

AraC-5''-methylthioacetate (araC-MTA, 1) and araC-5''-butylthioacetate (araC-BTA, 2) were prepared and their physical and chemical properties and in vivo antitumor activities were examined. Both compounds were found to have higher partition coefficients (n-hexanol/water) than their parent araC and to be hydrolyzed to araC within an hour in mouse plasma and ascitic fluid solutions. In in vivo antitumor activity test they showed similar potency to araC, which were assumed due to too quick hydrolyses of them to parent in the body fluid.