약물과 생체 고분자간의 상호작용(XI) Cefaclor, cefpiramide, ceftazidime and ceforanide와 소혈청 단백과의 결합에 관한 연구

• 영문명: Drug-Biomacromolecule Interaction(XI) Binding of cefaclor, cefpiramide, ceftazidime and ceforanide to bovine serum albumin
• 발행기관: 대한약학회
• 저자명: 김종국(Chong Kook Kim) 권경희(Kyeng Hee Kwon)
• 간행물 정보: 『약학회지』제32권 제3호 (1988년), 182~186쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.06.29

영문 초록

Binding of four cephalosporins(cefaclor, cefpiramide, ceftazidime, ceforanide) to bovine serum albumin was studied. Difference spectrophotometry was employed to evaluate the nature and the degree of association of cephalosporin-albumin complex. 2-(4''-hydroxybenzenazo)benzoic acid was used as the uv spectrophotometric probe for measuring the binding of cephalosporins to bovine serum albumin. Competitive bindings between cephalosporins and probe were observed. For the binding of cephalosporins to bovine serum albumin, three binding sites were identified. The binding constants of cefaclor, ceforanide, ceftazidime and cefpiramide were 12.57 X 1O-2M-1, 6.49 X 1O-2M-1, 4.70 X 1O-2M-1 and 6.20 X 1O-2M-1 respectively.

키워드

Cefaclor ceftazidime ceforanide cefpiramide bovine serum albumin proteinbinding 2-(4'-hydroxybenzene azo) benzoic acid difference spectra drug interaction.