가스 크로마토그래피에 의한 아민노산 광학 이성질체의 분리(III) (S)-5-isobutyl-N3-phenyl-2-thiohydantoin의 광학 활성 고정상으로의 응용

• 영문명: Separation of Amino Acid Enantiomers by Gas Chromatography(III) (S)-5-isobutyl-N3-phenyl-2-thiohydantoin as chiral stationary phase
• 발행기관: 대한약학회
• 저자명: 박만기(Man Ki Park) 양정선(Jeong Seon Yang) 고창범(Chang Bum Ko)
• 간행물 정보: 『약학회지』제32권 제2호 (1988년), 112~116쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.04.29

영문 초록

The resolution of N-trifluoroacetyl(N-TFA) ter-isopropylesters of Ala, Ile, Leu, Val and Phe by gas chromatography on the (S)-5-isobutyl-N3-phenyl-2-thiohydantoin as stationary phase was investigated. The phase was employed at several column temperatures(140oC-200oC) and the separation factors were 1.18-1.45 range for five amino acid enantiomers. The possible mechanism of chiral recognition was investigated by NMR technique and the association constant(Kc) was calculated as 201.3(r=0.98) for alanyl derivative.