야채 및 과일추출물의 항산화작용

• 영문명: Antioxidant Activity of Vegetables or Fruits Extract in Mice
• 발행기관: 대한약학회
• 저자명: 허찬(Chan Heo) 김남이(Nam Yee Kim) 김현표(Hyun Pyo Kim) 허문영(Moon Young Heo)
• 간행물 정보: 『약학회지』제49권 제3호 (2005년), 249~254쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.06.30

영문 초록

The ethanol extracts of the mixed vegetables (Bioactive Vegetables, BV) and the mixed fruits (Bioactive Fruits, BF) were evaluated for their in vivo antioxidant activities. Four weeks treatment of oral administration was performed to mice. A KBrO3, as a potent oxidant was used to induce the oxidative stress for in vivo experiment. BV and BF were shown to possess the significant inhibitory effect of lipid peroxidation as measured by the level of malondialdehyde (MDA) formation although the potencies were not higher than those of well-known antioxidants such as vitamin C, trolox and quercetin. Furthermore, BV and BF inhibited DNA damage assessed by single cell gel electrophoresis (comet assay) and reduced the micronucleated reticulocyte (MNRET) formation of peripheral blood. Antioxidants tested also revealed potent inhibitory activities higher than BV and BF. These antigenotoxic activity profiles were similar to that of aboveentioned inhibition of lipid peroxidation. Therefore, BV and BF having mild antioxidant activity as functional food candidates may be useful natural antioxidants by the inhibiting of lipid peroxidation and the protecting oxidative DNA and chromosomal damage.

키워드

vegetable fruit antioxidant DNA damage chromosomal damage comet assay micronucleus assay in vivo