택란의 비만세포 매개 즉시형 알레르기 반응의 억제 효과

• 영문명: Ihibitory Effect of Lycopus lucidus on Mast Cell-Mediated Immediate-Type Allergic Reactions
• 발행기관: 대한약학회
• 저자명: 김숙현(Suk Hyun Kim) 김대근(Dae Keun Kim) 임종필(Jong Pil Lim) 체병숙(Byeong Suk Chae) 신태용(Tae Yong Shin)
• 간행물 정보: 『약학회지』제46권 제6호 (2002년), 405~410쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.12.31

영문 초록

The effect of aqueous extract of Lycopus lucidus Turcz. (Labiatae)(LLAE) on mast cell-mediated immediatetype allergic reactions was investigated. LLAE (0.01 to 1 mg/g) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80. LLAE (0.001 to 1 mg/g) also dose-dependently inhibited local anaphyBaKis activated by anti- dini-trophenyl DNP) IgE. When LLAE was pretreated at the same concentration with syatemic anaphylaxis, serum histamine levels were reduced in a dose-dependent manner, LLAE (0.001 to 1 mg/ml) dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. The level of CAMP in human mast cell line (HMC-1) cells, when LLAE (1mg/ml) was added, aignificanoy was increased, compared with that of normal control. These results provide evideNes that LLAE may be benescial in the treatment of allergic diseases.

키워드

Lycopus lucidus anaphylaxis compound 48/80 anti-dinitrophenyl(DNP) IgE cAMR histamine mast cells.