넘취 정유의 Murine Macrophage Raw 264.7세포에서 in vitro항염효과

• 영문명: in vitro Antiinflammatory Activity of the Essential Oil from Lingularia fischeri var. spiciformis in Murine Marcrophage Raw 264.7 Cells
• 발행기관: 대한약학회
• 저자명: 김륭규(Ryung Gyu Kim) 신경민(Kyung Min Shin) 천성국(Sung Kuk Chun) 지사영(Sa Young Ji) 서성훈(Seong Hoon Seo) 박희준(Hee Juhn Park) 최종원(Jong Won Choi) 이경태(Kyung Tae Lee)
• 간행물 정보: 『약학회지』제46권 제5호 (2002년), 343~347쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.10.31

영문 초록

In the present study, effects of essential oils isolated from various plants have been evaluated on lipopolysaccharide (LPS)-induced release of nitric oxide (NO), prostaglandin E2(PGE2) and tumor necrosis factor-α(TNF-α) by the macrophage RAW 264.7 cells. Among the tested essential oils, essential oil of Lingularia fischeri var. spiciformis (LF-oil) signifcantly inhibited the LPS-induced generation of NO, PGE2 and TNF-αIn Raw 264.7 cells. Consistent with these observations, the expression of inducible NO synthase (Inos) and cyclooxygenase (COX)-2 enzyme was inhibited by LF-oil in a concentration- dependent manner Thus, this study suggests that inhibition of release of Inos, COX-2 expression, and TNF-α By the essential oil of Lingularia fischer may be one of the mechanisms responsible for the anti-inflammatory effects of this medicinal plant.

키워드

Ligularia fischeri var. spiciformis nitric oxide RAW 264.7 COX-2 prostaglandin E2 iNOS TNF-a.