덱스트로메토르판에 대한 한국인의 표현헝 및 유전자헝 분석

• 영문명: Metabolic Phenotyping and Genotype of Dextromethorphan in Korean
• 발행기관: 대한약학회
• 저자명: 정희선(Hee Sun Chung) 양원경(Won Kyung Yang) 최화경(Hwa Kyung Choi) 양영근(Young Keun Yang) 한은영(Eun Young Han) 정운계(Wun Kye Chung) 유영찬(Young Chan Yoo)
• 간행물 정보: 『약학회지』제46권 제3호 (2002년), 179~184쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.06.29

영문 초록

The abuse of dextromethorphan has been prevalent for 15 years in Korea and its fatal cases were reported even though it has proved to be very safe. In this study; to investigate the safety and tolerance assessment of deitromethorphan, the metabolic phenotyping and genotype of dextromethorphan were studied. After a single 30 mg of dextromethorphan oral administration to 74 volunteers, concentration of dextromethorphan and its metabolites, dextrorphan, hydroxymorphinan and methoxymorphinan were measured in urine which collected during 8hrs after the drug administration. CYP2D6 phenotype was determined from the ratio of dextromethorphan to dextrorphan. GC/MS was used to quantify dextromethorphan and its metabolites. For genotyping, mutant alleles of the CYP2D6 gene were identified.24 subjects (32.4%) were homozygous for CYP2D6*10B, 29 subjects (39.2%) were heterozygous for thIns allele, while in 21 subjects (28.4%) no exon 1 mutation could be found. The frequency of CYP2D6*10B-allele containing the 188C T mutation was 54% of total subjects studied.

키워드

drug abuse dextromethorphan dextrorphan CYP2D6 phenotype genotype.