수용액에 있어서의 Indomethacin 분해

• 영문명: The Degradation of Indomethacin in Aqueous Solution
• 발행기관: 대한약학회
• 저자명: 전인구(In Koo Jeon) 이민화(Min Wha Lee) 우종학(Chong Hak Woo)
• 간행물 정보: 『약학회지』제20권 제2호 (1976년), 76~82쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1976.06.30

영문 초록

The base-catalyzed hydrolysis of indomethacin over a range of pH 8.2 to 10.0 was investigated, according to the first order kinetic equation. The energy of activation for the reaction was calculated 20.18kcal/mole from the Arrhenius plot. And the optimal pH of indomethacin in aqueous solution was estimated as pH 4.93 by the extrapolation of the log k-pH profiles in strong acidic and alkaline regions. And the influences of alkaline earth metals, heavy metals and some other compounds on the degradation of indomethacin were observed with no effect.