혼합용매중에서의 산-고기 지시약에 관한 연구(I) : 수-유기용매 혼합용매중 Ampicillin, Amoxicillin 및 Cephalexin의 정량

• 영문명: Studies on Acid-Base Indicators in the Mixtures of Some Solvents(I) : Determination of Ampicillin, Amoxicillin and Cephalexin in Aqueous Organic Solvents
• 발행기관: 대한약학회
• 저자명: 이왕규(Wang Kyu Lee) 심창구(Chang Koo Sim)
• 간행물 정보: 『약학회지』제20권 제1호 (1976년), 32~36쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1976.03.31

영문 초록

The pH titration curves of ampicillin, amoxicillin and cephalexin in aqueous acetone, ethanol and N,N'-dimethylformamide by use of 0.02 N-KOH solution showed that 80% acetone was the most effective solvent for alkali titration of them. The pH jumps of samples in 80% acetone were sharp enough to determine the contents of them by use of potentiometric titration. The pKa value of brom thymol blue in 80% acetone (9.4) was coincided with each equivalent point of ampicillin, amoxicillin and cephalexin, but those of phenolphthalein, thymolphthalein, thymol blue and brom cresol purple were not. The color change of brom thymol blue at equivalent points was very clear except the case of amoxicillin that the determination of samples in 80% acetone with 0.02 N-KOH solution by the aid of brom thymol blue could be available.