방향족 활성 Chloro화합물의 Alkoxy기 치환에 관한 연구

• 영문명: Stydies on the Substitution of the Activated Aromatic Chloride with Alkoxy Group.
• 발행기관: 대한약학회
• 저자명: 조윤상(Youn Sang Cho) 공영식(Yung Sik Kong)
• 간행물 정보: 『약학회지』제19권 제2호 (1975년), 101~110쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1975.06.30

영문 초록

p-Chloronitroobenzene(substrate) and p-nitrophenetole (product) were quantitatively analyzed to know the degree of extent of reaction in the process of time. The calibration curve was prepared by the internal standard method in gaschromatography. 2,6-Dimethylnaphthalene was used as internal standard. The rate constant(k), the reaction velocity in various concentrations and amounts of ethanol, the change of reaction velocity with the amounts of NaOH altered, and the formation of byproducts(azo-compound -and p-nitrophenol) with the amounts of MnO2m and NaOH altered, were studied. From the results of these experiments, this reaction was second order and the rate constant was k=10.3 X 10-3 mole-1.min-1. When p-chloronitrobenzene 1 pt., NaOH 0.56pts. MnO2 0.5pts., and ethanol 25pts-were reacted about 10 hours, p-nitrophenetole was nearly quantitatively obtained without byproducts.