Malon 산 Ester 유도체와 요소와의 축합에 관한 연구

• 영문명: Studies on the Condensation with Malonates and Urea
• 발행기관: 대한약학회
• 저자명: 국채호(Che Ho Cook) 조윤상(Youn Sang Cho) 주상섭(Sang Sub Jew)
• 간행물 정보: 『약학회지』제18권 제2호 (1974년), 125~132쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1974.06.30

영문 초록

The by-products which were occurred in the synthesis of 5-ethyl-5-phenyl barbituric acid were isolated by column chromatography combined with gas-liquid chromatography and were identified by elemental analysis, ir, nmr and mass spectroscopy ; major by-products were ethyl alpha-phenylbutyrate and alpha-phenylbutyramide. The alkoxide which was known to be a condensation agent not only accelerated the condensation but also did the decarboxylation. And the entity concerned with the condensation with diethyl ethylphenylmalonate was not urea but N-monosodium urea.