복령의 이뇨작용

• 영문명: Diuretic Action of Hoelen in the Dog
• 발행기관: 대한약학회
• 저자명: 이돈일(Dohn Ill Lee) 고석태(Suk Tai Ko) 문영희(Yung Hee Moon)
• 간행물 정보: 『약학회지』제18권 제1호 (1974년), 39~48쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1974.03.30

영문 초록

Intravenously administered total water extract of Hoelen, (Pachymae fungus) in a dose of 10mg/kg and its methanol extract, in a smaller dose than total water extract, produced significantly increases on urinary volume, sodium and potassium excretion, and osmolar and free water clearances. Increasing the doses produced more pronounced renal responses. Glomerular filtration rate and renal plasma flow changed little with both extract. On the contrary, water extract from residue obtained on extraction with organic solvents exhibited no significant changes on the parameters of the renal function. In experiments, in which the total water extract was infused directly into a renal artery and urines from both ureters were collected separately, a small dose of 0.3mg/kg/min showed no diuresis, but a large dose of 1.0mg/kg/min elicited diuretic action even on the contralateral kidneys. It is, therefore, concluded that Hoelen induces diuresis, mainly by inhibiting reabsorption of electrolytes in the renal tubules, and that the renotropic action may be mediated by some endogenous humoral substances.