부교감신경차단성약물이 Sulfa제의 흡수에 미치는 영향에 관한 연구

• 영문명: Studies on the Effect of various Parasympatholytic Agents to the Absorption of some Sulfonamides
• 발행기관: 대한약학회
• 저자명: 김재완(Jae Wan Kim)
• 간행물 정보: 『약학회지』제12권 제1&2호 (1968년), 16~31쪽, 전체 16쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1968.06.30

영문 초록

Comparative studies were made on some sulfonamides, used individually and combined with parasympatholytic agents as regards (1)the absorption rate through isolated rat small intestine (in vitro), (2) the absorption rate through rat small intestine (in vivo), and (3) the blood concentration of sulfonamides were examined by its oral administration with each combined drug to rabbits, and the following effects were found, parasympatholytic agents inhibit the absorption of sulfonamides from the small intestinal tract. Comparison of the inhibitic effeciency of parasympatholytic agents is as follows: oxazepam, oxyphencyclimine hydrochloride, probantheline bromide, atropine sulfate (The examples are from the weakest to the strongest). Decrement of the absorption rate of sulfonamides is as follows: sulfadiazine, sulfathiazole, sulfamethoxypyridazine, sulfadimethoxine, sulfamerazine, sulfamethazine (The example are from the strongest to the weakest). Additionally, it is assumed that if the combined drugs were absorbed from the small intestine in the original form, those inhibitic effects should be best regarding to their sulfonamide per parasympatholytic agent combined rate "25 : 1" than to their any other rates.