Ester형 Chloramphenicol의 생체내 대사에 대하여

• 영문명: Metabolic fate of chloramphenicol-ester
• 발행기관: 대한약학회
• 저자명: 한병훈(Byung Hoon Han)
• 간행물 정보: 『약학회지』제8권 제1호 (1964년), 1~5쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1964.03.30

영문 초록

Present experiment in vivo shows that some conversions of active groups in chloramphenicol residue of ester, that is hydrolytic cleavage of dichloracetamide and glucuronide formation, seem to take place prior to hydrolysis. This result suggest that the enzymatic hydrolysis rate in vitro, is not available as an index for the evaluation of the chloramphenicol ester potency.