학술논문
Alkyl 급 Aryl thionocarbamate 류의 합성과 그 구충작용에 관한 연구
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- 영문명
- Preparation of Alkyl and Aryl-thionocarbamate and their Anthelmintic action
- 발행기관
- 대한약학회
- 저자명
- 국채호(Che Ho Cook)
- 간행물 정보
- 『약학회지』제7권 제2&3호 (1963년), 58~66쪽, 전체 9쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 1963.09.30
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국문 초록
영문 초록
Alkyl-phenylthionocarbamates already have been investigated as anthelmintics. Especially ethyl-phenylthionocarbamate is noted for its anthelmintic action. Author studied methods for synthesizing Alkyl-phenyithionocarbamates, Alkyl-p-phenetyl thionocarbamates, Alkyl-cyclohexylthionocarbamates, 5 kinds for each. For alkyl radical -CH3, -C2H5, -n-propyl, -isobuthyl, -n-butyl, being chosen. Compounds VIII, X, XIII, XIV, and XV are new compounds. At the sametime author prepared 4 kinds of Aryl-thionocarbamates, among which XVII, and XIX being new compounds. (Table I) The antheimintic action of these thionocarbamates has been examined through kymographic records indicating the action of neuromuscular preparation of Eisenia foetida Savigny in the various concentration of above compounds:-Trendelenburg method. Santonine as the criterion of the estimation. (Table. II) 1. Compounds I-X could be prepared by method A or method B. method A in sealed tube brought on better yield and purity. w. Compounds XI-XV couldn't be prepared by method A but by method B. 3. Aryl-thionocarbamates XVI, XVII, XVIII, and XIX Couldn''t be prepared by method A or method B but by method C. 4. Analyzed N. contained in all compounds. Analyzed C.H. and N. contained in unknown compounds, VIII, X, XIII, XIV, XV, XVII, and XIX. 5. Examination of anthelmintic action has been done under the advice of Prof. J.S. Ohmedical college, Seoul Nat. University. 6. Compounds VI-X showed little action. 7.Compounds XVI-XIX showed almost no action. 8. Compounds XI-XV .showed stronger action than compounds I-V, which was reported already as a usable anthelmintics. 9. Compounds XI, XII, XIII and XIV showed strongest actions, stronger than santonine as recorded on kymographion of the Trendelenburg method. Provided that, the toxity of these compounds found mild enough for human system, these compounds will serve as anthelmintics of greater powers than compounds I-V. 10. In Alkyl-thionocarbamates, R''NH-radical.
목차
키워드
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