2-Acetyl-11-Keto-deltal2 : 13-Oleanolic Ketol Acetate 급 기타 유도체의 합성

• 영문명: Synthesis of 2-Acetyl 11-keto delta12:13 Oleanolic ketol acetate and other derivatives.
• 발행기관: 대한약학회
• 저자명: 김경호(Kyung Ho Kim)
• 간행물 정보: 『약학회지』제6권 제1호 (1962년), 25~27쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1962.05.30

영문 초록

The derivative of glycyrrhetinic acid which have similar effects of desoxycorticosterone acetate was prepared glycyrrhetinyl chloride by the chlorination with thionyl chloride at low temperature. 2-Acetyl-11-keto-delta12 : 13 oleanolic ketol acetate (30) was synthesized by diazotating glycyrrhetinyl chloride with diazomethan and the acetylation with anhydro acetic acid. 2-Acetyl-delta12 : 13 oleanolic ketoi acetate (28) was synthesized by chlorinating oleanolic acid with thionyl chloride, and by diazotating oleanolyl chloride with diazomethan and the acetylation with anhydroacetic acid.