장용피기제에 관한 연구(제1보) Invitro Test에 의한 기제의 선택에 대하여

• 영문명: Studies on Enteric Coating Bases. I Selection of Enteric Coating Bases by Invitro Test
• 발행기관: 대한약학회
• 저자명: 김수억(Soo Uck Kim) 치달현(Dal Hyun Chi) 문정현(Jung Hyun Mun) 이금정(Kum Jung Lee)
• 간행물 정보: 『약학회지』제5권 제1호 (1960년), 31~36쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1960.10.30

영문 초록

The importance of enteric coating technique among the pharmaceutical firms has recently risen very significantly. This study of enteric coating bases was made in order to determine the most suitable bases and dusting powders. Materials and equipment used in this experiment are shown in table I and kinds of enteric coating bases and their formulas are shown in table 2. The evaluation of the suitability for enteric coating bases and dusting powder was made by disintergration test after measuring the thickness of the enteric coated layer as shown in the tables 4 and 5. Based on the results of this study, the base D(shellac 20 Gm, anhydrous lanoline 5 Gm, 96% alcohol 75ml) and the base E (shellac 10 Gm, cetyl alcohol 10 Gm. acetone 80ml) are selected among the 8 kinds of bases studied in a preliminary test and it was found that Mg-stearate and Ca-stearate were in most suitable dusting powders among the 6 kinds studied for the bases D and E. Further study on bases D and E was carried out by varying the proportions of the materials which were the orginal constituents of bases D and E. According to the result of this further study shown in table 6, the shellac 15 Gm cetyl alcohol 5 Gm Acetone 80ml of base E is recommended as the most suitable dusting powder.