(3aR*,6aS*)-6a-Hydroxy-cyclopenta[b]pyrrole-3a-carboxylate의 부제합성 및 NMR 스펙트럼을 통한 입체구조의 결정

• 발행기관: 대한약학회
• 저자명: 권순경(Soon Kyung Kwon) 박명숙(Myung Suk Park) 서원준(Won Jun Seo)
• 간행물 정보: 『약학회지』제38권 제5호 (1994년), 544~554쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.10.30

영문 초록

Pyrrolidine-2,3-dione derivative A was synthesized from oxalylation of chiral enamine Ba. The stereostructure of its major diastereomer (Amaj) was determined as octahydro-2,3-dioxo-6aS-hydroxy-1-(1S-methoxycarbonyl-2-phenylethyl)-cyclopenta[b]pyrrole-3aR-carboxylic acid ethyl ester Aa by means of NMR spectrum. This result implied that the asymmetric carbon-carbon bond forming reaction occurred preferentially at the beta-face of Ba.