인체 및 고등 동물에서 생성되는 디기탈리스 유사체의 탐색

• 영문명: A Search for Endogenous Digitalis-like Factors
• 발행기관: 대한약학회
• 저자명: 송영순(Ryung Soon Song-Kim)
• 간행물 정보: 『약학회지』제30권 제4호 (1986년), 198~201쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.08.30

영문 초록

The successful elucidation of the opiate receptor and its natural ligands has generated speculation that other drugs might interact with cellular sites designed to accommodate endogenous mediators. The properties of binding sites for the cardiac glycosides(CG), together with the potency and specificity of the digitalis drugs suggest that CG mimic an endogenous digitalis-like factor. Recently, several laboratories have reported the potency in mammalian tissues and fluids of unidentified materials that share certain specific properties of the CG. Identification of body''s own digitalis might yield a natural compound whose synthetic analogs may provide safer and more effective drugs than can be achieved by structural modification of the CG of plant origin.