가토에 있어서 Capsaicin의 흡수 및 배설에 관한 연구

• 영문명: Study on the Absorption and Excretion of Capsaicin in Rabbits
• 발행기관: 대한약학회
• 저자명: 김낙두(Nak Doo Kim) 박찬용(Chan Yong Park)
• 간행물 정보: 『약학회지』제25권 제3호 (1981년), 101~108쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1981.09.30

영문 초록

Quantitative determination of capsaicin in biological fluid was investigated. The pharmacokinetic study of capsaicin in rabbits was performed by high-pressure liquid chromatography, equipped with a microparticulate reversed-phase column and a fixed wavelength detector. Elution was carried out using methanol-water(70:30). It allows the quantitative determination at 8~400ng level. When single dose of capsaicin(4mg/kg) was given to rabbits intravenously, the elimination phase was extremely short with average half-life to 17.35 minute. Urine excretion of capsaicin itself during first 2 hours after intravenous administration (4mg/kg) was 0.004~0.04% of the administered amount. The maximum plasma concentration of capsaicin after oral administration (300mg/kg) was 4 X 1O-7g/ml at 40 minutes. The LD50 of capsaicin in mouse was 0.40mg/kg (i.v.) and 47.2mg/kg (p.o.) which was determined by Litchfield and Wilcoxon''s method, suggesting that the gastrointestinal absorption of capsaicin is poor.