Shikonin의 지시약적 성질에 관한 연구

• 영문명: Studies on Color Transition Mechanism of Shikonin
• 발행기관: 대한약학회
• 저자명: 이왕규(Wang Kyu Lee) 류경수(Gyong Soo Yoo)
• 간행물 정보: 『약학회지』제24권 제3&4호 (1980년), 151~157쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1980.12.30

영문 초록

Color transition mechanism of shikonin as an acid-alkali indicator was studied. It was confirmed that the presence of phenolic hydroxy radical was essential for the color change of shikonin. But in accordance with shikonin sodium salt (blue color), which was presumed to make chelation as six membered rings. Shikonin in alkaline solution, by dissociated phenolic protons of naphthoquinone nucleous, converted to the corresponding anion and instead of disappearance tautomerization, electron delocalization occurred and an additional pair of nonbonding electrons in the anion was available for interaction with pi electron system of the ring with further extension of the conjugation. It was responsible for its blue color(corresponding color: orange) with needs less energy difference (pi->pi*) because of conjugation extension. Shikonin sodium salt seems to have similar nuclear structure as shikonin anion.