Sodium Cloxacillin의 유기용매에 의한 결정화 및 안정성에 관한 연구

• 영문명: Studies on the Crystallization in Organic Solvents and the Stability of Sodium Cloxacillin
• 발행기관: 대한약학회
• 저자명: 백우현(Woo Hyun Paik) 김정우(Jung Woo Kim) 봉득환(Deuk Whan Bong)
• 간행물 정보: 『약학회지』제22권 제1호 (1978년), 8~14쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1978.03.31

영문 초록

The method that changes sodium cloxacillin from amorphous form to hydrate form was investigated. Using organic solvents of which dielectric constants are greater than 9, the amorphous sodium cloxacillin could be changed to hydrate form. The difference of water content of sodium cloxacillin hydrate caused the differences of ir spectrum at 3,350~3,360cm-1, and owing to the decrease of water content, hydrate form was changed to the amorphous form, which could be identified by x-ray diffraction pattern. Regarding the stability of sodium cloxacillin in activity, the hydrate form was stable but the amorphous form was very unstable. Moreover, the stable hydrate form was scarcely hygroscopic, while the other form was hygroscopic, becoming a fused state at 50o and R.H. 50%.