칼시토닌 고분자 미립자 투여에 따른 골다공증 유발 쥐의 골밀도 변화

• 영문명: Change of Bone Mass Density as Injection of Calcitonin-microsphere in Osteoporosis-Induced Rats
• 발행기관: 대한임상노인의학회
• 저자명: 최정원(Jeong won Choi) 정제순(Je soon Jung) 이상건(Sang Gun Lee) 백두진(Doo Jin Paik) 박일규(Il Kyu Park) 박용구(Yong Goo Park) 김미정(Mi Jung Kim)
• 간행물 정보: 『대한임상노인의학회지』대한임상노인의학회지 제4권 제4호, 39~46쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.12.30

영문 초록

Objective: To evaluate bone protective effects of salmon calcitonin microspheres against cancellous bone loss in ovariectomized rats. Method: Thirty five osteoporosis-induced Sprague-Dawley rats were randomly divided into five groups (high dose calcitonin group (112 U/kg), low dose calcitonin group (56 U/kg), free calcitonin group, only ovariectomy group, control group). Ovariectomized rats were injected s.c. with salmon calcitonin microspheres(l12 U/kg or 56 U/kg) weekly, and free salmon calcitonin on alternate days. control rats and the remaining ovariectomized rats were injected s.c. on alternate days with saline vehicle. The effects and side effects in each group were assessed by the bone mineral density and bone histomorphomeσy. Results: 1. At four months after the ovariectomy, the bone mineral densities in high dose calcitonin group were 0.1640±0.0156 grn/㎠, the bone mineral densities in low dose calcitonin group were 0.1600±0.0114 gm/㎠, the bone mineral densities in calcitonin group were 0.1531±0.0168 gm/㎠, the bone mineral densities in ovariectomy group were 0.1404±0.0070 gm/㎠, the bone mineral densities in control group were 0.1896±0.0163 gm/㎠. The bone mineral densities of the femur in ovrariectomy groups compared with control group were decreased with time. The difference of the bone mineral densities between high and low dose calcitonin group and ovariectomy groups was significant (p<0.05). 2. We found that the bone trabeculi in bone histomophometry were more maintained in high dose calcitonin group compared with ovariectomy group. Conclusion: 1. Bone mineral densities of salmon calcitonin microsphere injected rats was higher than only ovariectomized rats in femur. 2. Bone mineral densities of salmon calcitonin microsphere injected rats had no significant differences than only ovariectomized rats in L5 vertebra. 3. In histologic examination, salmon calcitonin microsphere and free salmon calcitonin injected rats showed more prominent bony trabeculae than ovariectomized rats.

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참고문헌

키워드

Osteoporosis Calcitonin-microsphere Bone mineral density Bone histomorphometry