전두측두엽 치매의 임상 양상과 치료적 접근

• 영문명: Clinical Features and Therapeutic Approaches of Frontotemporal Dementia
• 발행기관: 대한노인정신의학회
• 저자명: 이강준(Kang Joon Lee)
• 간행물 정보: 『노인정신의학』노인정신의학 제16권 제2호, 67~74쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2012.12.31

영문 초록

Frontotemporal dementia (FTD), formerly called Pick’s disease, is a progressive dementia that is associated with focal atrophy of the frontal and/or temporal lobes. FTD has three major clinical subtypes ; 1) a frontal variant of frontotemporal dementia (fvFTD), 2) semantic dementia (SD), and 3) progressive nonfluent aphasia (PNFA). These different variants differ in their clinical symptoms, cognitive deficits, and affected brain regions. The insidious onset of personality changes and behavioral abnormalities is the most prominent feature of fvFTD. Poor insight, loss of personal and social awareness, and blunting of affect are common be-havioral changes in fvFTD. The most common presenting complaint in SD involves language, and is often described as a loss of memory for words or a loss of word meaning. Patients with PNFA present with changes in fluency, pronunciation, or word finding difficulty. An accumulating body of evidence suggests that FTD overlaps with three other neurodegenerative diseases: motor neu-ron disease (MND), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP). Treatment for FTD consists of behavioral and pharmacological approaches. Medications such as selective serotonin reuptake inhibitors, antipsychotics have used in FTD. Cholinesterase inhibitors do not consistently improve cognitive and behavioral symptoms of FTD. Further research should be directed at developing new therapeutic methods to improve the patients’ symptoms.

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전두측두엽 치매의 치료

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키워드

전두측두엽 치매 어의 치매 진행성 비유창실어증 Frontotemporal dementia Semantic dementia Progressive nonfluent aphasia