Activated microglial cells synthesize and secrete AGE-albumin

• 발행기관: 대한해부학회
• 저자명: Kyunghee Byun Enkhjaigal Bayarsaikhan Daesik Kim Myeongjoo Son Junhee Hong Goo-Bo Jeong Sun Ha Paek Moo-Ho Won Bonghee Lee
• 간행물 정보: 『Anatomy and Cell Biology』Vol.45(1), 47~52쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2012.03.31

영문 초록

A holy grail of curing neurodegenerative diseases is to identify the main causes and mechanisms underlying neuronal death. Many studies have sought to identify these targets in a wide variety of ways, but a more important task is to identify critical molecular targets and their origins. Potential molecular targets include advanced glycation end products (AGEs) that can promote neuronal cell death, thereby contributing to neurodegenerative disorders such as Alzheimer disease or Parkinson disease. In this study, we showed that AGE-albumin (glycated albumin) is synthesized in microglial cells and secreted in the human brain. Our results provide new insight into which microglial cells can promote the receptor for AGE-mediated neuronal cell death, eventually leading to neurodegenerative diseases.

목차

Abstract

Introduction

Materials and Methods

RESULTS

DISCUSSION

Acknowledgements

References

키워드

Microglia AGE albumin Cell death