학술논문
Expression and roles of NUPR1 in cholangiocarcinoma cells
이용수 13
- 영문명
- 발행기관
- 대한해부학회
- 저자명
- Ki-Sun Kim Du-Il Jin Sik Yoon Sun-Yong Baek Bong-Seon Kim Sae-Ock Oh
- 간행물 정보
- 『Anatomy and Cell Biology』Vol.45(1), 17~25쪽, 전체 9쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2012.03.31
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국문 초록
영문 초록
Nuclear protein-1 (NUPR1) is a small nuclear protein that is responsive to various stress stimuli. Although NUPR1 has been associated with cancer development, its expression and roles in cholangiocarcinoma have not yet been described. In the present study, we found that NUPR1 was over-expressed in human cholangiocarcinoma tissues, using immunohistochemistry. The role of NUPR1 in cholangiocarcinoma was examined by its specific siRNA. NUPR1 siRNA decreased proliferation, migration and invasion of human cholangiocarcinoma cell lines (HuCCT1 and SNU1196 cells). From these results, we conclude that NUPR1 is over-expressed in cholangiocarcinoma and regulates the proliferation and motility of cancer cells.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
References
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