섬망 치료에 있어 Aripiprazole과 Haloperidol의 효과 및 부작용 비교

• 영문명: Comparison of Efficacy and Side Effects between Aripiprazole and Haloperidol in the Treatment of Delirium
• 발행기관: 대한노인정신의학회
• 저자명: 이선화(Sun Hwa Lee) 박상진(Sang Jin Park)
• 간행물 정보: 『노인정신의학』노인정신의학 제15권 제1호, 31~37쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2011.06.30

국문 초록

최종 20명의 섬망 환자들에게 aripiprazole 또는 haloper-idol을 투여한 결과 두 군 모두 약물 치료 후에 K-DRS-98 점수의 유의한 감소를 보였지만, 두 군 사이에 차이는 없었다. 치료 후 두 군 모두 추체외로 증후군은 나타나지 않았으나, ari-piprazole 군은 치료 후 유의하게 혈중 프로락틴 농도가 감소하였고 이와 반대로 haloperidol 군은 혈중 프로락틴 농도가 증가하였다. Aripiprazole은 haloperidol만큼 섬망 치료에 효과적이었으며 haloperidol이 aripiprazole에 비해 혈중 프로락틴 상승과 연관성이 높았다.

영문 초록

Objectives：To compare the efficacy and the safety of aripiprazole and haloperidol in the treatment of patients with delirium. Methods：26 patients with delirium were randomized to receive either aripiprazole or haloperidol and finally 20 patients were analyzed. We collected demographic and clinical data. The Korean Version of Delirium Rating Scale-revised-98 (K-DRS-98) and Korean Version of Drug Induced Extrapyramidal Symptom Scale (DIEPSS-K) were assessed. Blood samples were collected to analyze serum sodium ion concentration, plasma cortisol and prolactin level and pulse oximetry was used for measuring oxygen saturation. Results：K-DRS-98 severity scores decreased in both groups significantly over the study period, but no statistically significant difference was observed between the two groups. No significant extrapyramidal syndromes were noted in both groups, but the use of haloperidol was associated with increased plasma prolactin level (From 24.0±28.1 ng/mL to 32.0±20.0 ng/mL, p=0.005). Conclusion：Aripiprazole is as effective as haloperidol in the treatment of delirium and aripiprazole may be safer than haloperidol in that haloperidol is associated with increased plasma prolactin level.

목차

서론

대상 및 방법

결과

고찰

요약

Acknowledgments

REFERENCES

키워드

Delirium Aripiprazole Haloperidol K-DRS-98 Extrapyramidal syndrome Hyperprolactinemia 섬망 추체외로 증후군 고프로락틴 혈증