The Study of Synergy between the BchE-k Variant and the ApoE Gene in the Alzheimer Dementia of the Korean Population

• 발행기관: 대한의학유전학회
• 저자명: Eun-Sim Shin Song-Ro Yoon Soo-Kyung Choi Soo-Young Kim
• 간행물 정보: 『대한의학유전학회지』제3권 제1호, 29~32쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.12.30

영문 초록

The Apolipoprotein E type 4 allele (ApoE ε4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease. The BchE-k variant, which is the common variant of the BchE gene, has been reported to show allelic association with AD in subjects who are also carriers of the ε4 allele of the ApoE, especially in subjects over the age of 75. This study was performed to evaluate the distribution of the ApoE and the BchE genotypes in the healthy and AD groups and to evaluate the synergy between the BchE-k variant and the ApoE ε4 in AD. The ApoE and the BchE genotypes were determined in DNA samples from 610 healthy people and 60 LOAD patients by using ARMS by standard agarose gel electrophoresis. The effect of the ApoE ε4 was closely related to AD(p＜0,05). A comparison between the AD patients and the healthy individuals, both with the ε4 allele, indicated an interaction between the BchE-k and the ApoE ε4(p＜0.05). The association of the BchE-k with AD was limited to carriers of the ApoE ε4 allele, among whom the presence of the BchE-k gave an odds ratio of AD 3,48 (95% C.I. 1.3-9.2). Therefore, these results suggested that further evidence of an association between the ApoE ε4 and LOAD, and the BchE-k acts in synergy with the ApoE ε4 as a susceptibility gene for AD.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Alzheimer dementia ApoE genotyping Butyrylcholinestesrase k variant