경도인지장애에서 구간거리 측정

• 영문명: Measurement of Interuncal Distance in Mild Cognitive Impairment
• 발행기관: 대한노인정신의학회
• 저자명: 전진숙(Jin Sook Cheon) 조원용(Won Yong Cho) 전갑수(Gap Soo Jeon) 송혜란(Hae Ran Song) 오병훈(Byoung Hoon Oh)
• 간행물 정보: 『노인정신의학』노인정신의학 제8권 제2호, 121~126쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2004.12.30

영문 초록

Objectives：The hippocampal atrophy has been known to be an important biological marker for the early diagnosis of mild cognitive impairment (MCI). The aims of this study are to disclose the differerence in the interuncal distance (IUD) between MCI, dementia of the Alzheimer's type (DAT) and healthy aged controls, and to identify the affecting factors. Methods：In transaxial plane, the IUDs at the level of the suprasellar cistern on the T1-weighted images on the brain MRI were measured in patients with MCI (N=30), those with DAT (N=34), and healthy aged controls (N=20). Furthermore, demographic data about age, sex, educational level as well as cerebrovascular factors were obtained by structured interviews and medical records, and the severity of cognitive disorders were assessed using the Mini-Mental Status Examination (MMSE), the Clinical Dementia Rating (CDR) and the Global Deterioration Scale (GDS). Results：1) The mean (±S.D.) IUD of DAT group (26.52±3.37 mm) was significantly different from that of healthy aged controls (24.35±2.91 mm)(p=0.044). However, there were no significant differences between IUD of MCI group (25.60±2.66 mm) and that of DAT group (p=0.483) as well as that of healthy aged controls and that of MCI group (p=0.363). 2) Variables such as age, sex, educational level, cerebrovascular risk factors and severity of cognitive disorder were not related to the IUD. Conclusions：The measurement of IUD on the brain MRI did not seem to be a helpful biological marker for the early detection of MCI in clinical practice.

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경도인지장애 해마위축 구간거리 Mild cognitive impairment Hippocampal atrophy Interuncal distance