진행된 원발성 간암 환자에서 방사선 치료 및 온열 요법에 따른 간 기능의 변화

• 영문명: Biochemical Changes of Liver Function in Patients with Hepatocellular Carcinoma Following Radiotherapy and Hyperthermia
• 발행기관: 대한방사선종양학회
• 저자명: 오영택 (Young Taek Oh) 성진실 (Jinsil Seong) 신현수 (Hyun Soo Shin) 김귀언 (Gwi Eon Kim)
• 간행물 정보: 『대한방사선종양학회지』제11권 제1호, 109~117쪽, 전체 9쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1993.06.30

영문 초록

To analyze biochemical changes of liver function following combined radiotherapy and hyperthemia, we reviewed retrospectively 37 patients with hepatocellular carcinoma treated with radiotherapy and hyperthermia between July 1988 and December 1990 at Department of Radiation Oncology, Yonsei Universtiy College of Medicine. Mean age was 52.7 years and male to female ratio was 11:1. The patients were classified as follows; to A and B group by Child's classification, to M and L group by irradiated volume, and subclassified into BM, BL, AM and AL group according to the combination of child's classification and irradiated volume. Radiation dose to the primary tumor was 3060 cGy with daily 180 cGy, 5 fraction per week using 10 MV of 4 MV linear accelerator. Hyperthermia (Themotron RF-8) was performed more than 4 times in all patients. Biochemical parameters including albumin (Alb), total bilirubin (T. Bil), aspartate aminotransferase (AST or SGOT), alanine aminotransferase (ALT or SGPT), and alkaline phosphatase (ALP) were regularly followed form 1 week before the treatment to 3 months after the treatment. The results are summerized as follows;1) In all the patient, mean ALP level peaked at 1 month, decreased at 2 months, slightly increased at 3 months after the treatment. Mean SGOT and SGPT levels peaked at 1 month after the treatment. Mean T.Bil level increased continuously and highest at 3 months after the treatment. Mean Alv level did not show significant changes;2) Mean ALP level retured to normal level at 3 month after the treatment in A but increased in A but increased in B group and the differences were statistically significant (p<001). Mean SGOT and SGPT levels peaked 1 month in A and 2 months after th treatment in B group. All the biochemical parameters did not show significant difference between M and L group. Mean ALP level increased at 3 months after the treatment in BM and BL groups and decreased in AM and AL groups. Mean SGOT level increased at 3 months after the treatment in BL groups;3) Hepatic failure occurred within 3 months after the treatment in 4 patients, all of whom were BL group. It is suggested that pre-treatment liver function and irradiated volume influence biochemical changes of liver in patients with hepatocellular carcinoma following combined radiotherapy and hyperthermia, and this treatment modality appears generally to be safe but might cause hepatic failure particularly in patient with poor liver function and laree treatment volume.

목차

abstract

서론

대상 및 방법

고찰

결론

참고문헌

키워드

Hepatocellular carcinoma Biochemical changes Radiotherapy Hyperthemia