방사선 조사 후 관찰한 가토 폐의 병리학적 변화

• 영문명: Pathologic Changes in the Rabbit lung Following Single Dose Irradiation
• 발행기관: 대한방사선종양학회
• 저자명: 이형식(Hyung Sik Lee) 최영민(Young Min Choi) 허원주(Won Joo Hur) 정진숙(Jin Sook Jeong) 유영현(Young Hyun Yuh) 이기남(Ki Nam Lee)
• 간행물 정보: 『대한방사선종양학회지』제12권 제2호, 143~150쪽, 전체 8쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1994.08.30

영문 초록

The damage which radiation produces in tissues such as the lungs can be discussed at the molecular, biophysical, cellular and organ levels. The cellular effects of irradiating the lungs are related to the histologic and clinical sequelae. In the present study the right lung of rabbits were exposed to single dose of 20 Gy of X-irradiation. Animals from each group wre sacrificed monthly for 6 months postexposure. Sections of lung were examined by light microscopy(LM) and by transmission electron microscopy(TEM). Multiple exudative lesions were seen at 2 months after the 20Gy irradiation and thery progressed to a proliferative and then reparative fibrotic lesion by 6 months. Changes in epithelial lining of lung components, particulary the presence of type Ⅱ pneumocytes were found by both LM and TEM. Capillary endothelial damages were less pronounced. The possible implication of cellular components in radiation pneumonitis and fibrosis is discussed.

키워드

Radiation pneumonitis fibrosis rabbit