원발성 간암의 방사선치료 및 온열요법의 병용치료 효과

• 영문명: therapuetic Effect of Combined Radiotherapy and Hyperthermia in Primary Hepatocellular Carcinoma
• 발행기관: 대한방사선종양학회
• 저자명: 강기문(Ki Mun Kang) 최일봉(Ihl Bohng Choi) 계철승(Chul Seung Kay) 최병옥(Byung Ok Choi) 정수미(Su Mi Chung) 김인아(In Ah Kim) 한성태(Sung Tae Han) 선희식(Hee Sik Sun) 정규원(Kyu Won Chung) 신경섭(Kyeong Sub Shinn)
• 간행물 정보: 『대한방사선종양학회지』제12권 제2호, 191~199쪽, 전체 9쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1994.08.30

영문 초록

Purpose : This study was undertaken to show the clinical resuts of combined radiotherapy and hyperthermia in primary hepatoma Materials and Methods : Between December 1989 and March 1993, 50 patients with hepatomas were treated by combined radiotherapy and hyperthermia. Among them, we analyzed retrospectively 33 patients who received the complete course of treatment. The ages of the patients ranged from 36 to 75(mean age : 55.5 years). Twenty six patients (78.8%) were men and 7 (21.2%) were women. According to Child's classification. nine patients (27.3%) were A group 9 (27.3%) were B group 15(45.4%) were C group. Radiation therapy was done by a 6 MV and 15 MV linear accelerator. Patients were treated with daily fractions of 150-180 cGy to doses of 2550 cGy-4950 cGy (median : 3000 cGy). Local hyperthermia was done by 8 MHZ RF capacitive heating device (Cancermia, Green Cross Co., Korea), 50-60 min/session, 1-2 sessions/wk, and 8.5 sessions (median number)/patient. We analyzed the prognostic factors including age, sex, tumor type, Child's classification, α-fetoprotein, liver cir-rhosis, ascites, portal vein invasion, esophageal varix, number of hyperthermia, chemotherapy, total bilirubin level, Karnofsky performance status. Results : The overall 1-year survival was 24.2% with a mean survival of 10 months. Of 33 patients, tumor regression (PR+MR) was seen in 30.4% no response was seen in 52.2%, 17.4% patient was progressed. In patients who had tumor regression, the overall 1 year survival was 42.1% with a mean survival of 14 months. Factors influencing the survival were sex (p=0.05), tumor type (p=0.0248). Child's classification (p=0.0001), liver cirrhosis (p=0.0108), ascites (p=0.0009), and Karnofsky performance status (p=0.0028). Complications developed in 28 patients, including 18 hot pain 5 fat necrosis, 3 transient fever, 2 nausea and vomiting. Conclusion : In this study the results suggests that combined radiotherapy and hyperthermia may improve the survival rate of hepatoma.

키워드

Primary Hepatocellular Carcinoma Radiotherapy Hyperthermia