Identification of Plasma Biomarkers in Drug-Naïve Schizophrenia Using Targeted Metabolomics

• 발행기관: 대한신경정신의학회
• 저자명: Qiao Su Fuyou Bi Shu Yang Huiming Yan Xiaoxiao Sun Jiayue Wang Yuying Qiu Meijuan Li Shen Li Jie Li
• 간행물 정보: 『Psychiatry Investigation』제20권 제9호, 818~825쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.09.30

영문 초록

Objective Schizophrenia (SCZ) is a severe psychiatric disorder with unknown etiology and lacking specific biomarkers. Herein, we aimed to explore plasma biomarkers relevant to SCZ using targeted metabolomics. Methods Sixty drug-naïve SCZ patients and 36 healthy controls were recruited. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. We analyzed the levels of 271 metabolites in plasma samples from all subjects using targeted metabolomics, and identified metabolites that differed significantly between the two groups. Then we evaluated the diagnostic power of the metabolites based on receiver operating characteristic curves, and explored metabolites associated with the psychotic symptoms in SCZ patients. Results Twenty-six metabolites showed significant differences between SCZ patients and healthy controls. Among them, 12 metabo-lites were phosphatidylcholines and cortisol, ceramide (d18:1/22:0), acetylcarnitine, and γ-aminobutyric acid, which could significantly distinguish SCZ from healthy controls with the area under the curve (AUC) above 0.7. Further, a panel consisting of the above 4 metab-olites had an excellent performance with an AUC of 0.867. In SCZ patients, phosphatidylcholines were positively related with positive symptoms, and cholic acid was positively associated with negative symptoms. Conclusion Our study provides insights into the metabolite alterations associated with SCZ and potential biomarkers for its diagnosis and symptom severity assessment.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

키워드

Schizophrenia Metabolomics Plasma Biomarker Phosphatidylcholines