Ghrelin Modifies the Impact of Life Stress on Suicidality in Patients With Acute Coronary Syndrome

• 영문명: Ghrelin Modifies the Impact of Life Stress on Suicidality in Patients With Acute Coronary Syndrome
• 발행기관: 대한신경정신의학회
• 저자명: Jae-Min Kim Hee-Ju Kang Ye-Jin Kim Ju-Wan Kim Wonsuk Choi Ju-Yeon Lee Sung-Wan Kim Jung-Chul Kim
• 간행물 정보: 『Psychiatry Investigation』제20권 제4호, 369~373쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.04.30

영문 초록

Objective This study investigated associations of life stressors and serum ghrelin levels with suicidal ideation (SI), and evaluated the potential mediating effect of ghrelin on associations between life stressors and SI in patients with acute coronary syndrome (ACS). Methods In total, 969 ACS patients recruited from a tertiary university hospital in Korea within 2 weeks of disease onset were evaluated in terms of life stressors (using the List of Threatening Events Questionnaire), serum ghrelin levels, and SI (using the “suicidal thoughts” item of the Montgomery–Asberg Depression Rating Scale). Covariates included sociodemographics, depression, vascular risk factors, and disease severity. After 1 year, 711 patients were re-evaluated in terms of SI; logistic regression was performed with adjustment for covariates. Results Life stressors were significantly associated with SI at baseline and follow-up. Serum ghrelin showed no such associations, but high levels thereof mediated associations of life stressors with SI; significant interaction terms were also observed after adjustment for covariates. Conclusion By evaluating life stressors and serum ghrelin levels, clinical prediction of SI in the acute and chronic phases of ACS could be improved.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Ghrelin Life stress Suicidal ideation Acute coronary syndrome