개머루덩굴 추출물의 자극에 의한 피부장벽 개선 효과

• 영문명: Effect of Ampelopsis brevipedunculata (Maxim.) Trautv extract on skin barrier function
• 발행기관: 한국축산식품학회
• 저자명: 박선경 임형진 원영선 박은재 오제훈 김지은 이민지 이소영 이승웅 이승재 노문철
• 간행물 정보: 『Food and Life』제2023권 제1호, 13~18쪽, 전체 6쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2023.03.31

영문 초록

The skin is the largest organ that blocks invasion to the outside. Due to external stimuli, the skin barrier collapses and immune function abnormalities occur. This leads to skin diseases such as atopic dermatitis and psoriasis. Through this study, we attempted to develop a natural material that can be used for various dermatitis diseases. In this study, the gene expression of skin barrier-related proteins was confirmed using tumor necrosis factor-α/interferon-γ-stimulated HaCaT cells through real-time PCR. As a result, it was confirmed that the gene expression of skin barrier-related proteins and ceramide-related proteins was improved by the ABE-M. In this study, it was confirmed that the gene expression of filaggrin, involucrin, and loricrin, which are skin barrier-related proteins, was improved by ABE-M, and it was confirmed that the gene expression of the tight junction-related proteins, occludin and zonula occludens proteins-1, was also increased. As such, it is expected that ABE-M can be used as a material for skin inflammation such as atopic dermatitis.

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키워드

skin barrier tight junction serine palmitoyltransferase (SPT) ceramidase