학술논문
Antioxidation and anti-inflammatory effects of gamma-irradiated silk sericin and fibroin in H₂O₂-induced HaCaT Cell
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- 영문명
- Antioxidation and anti-inflammatory effects of gamma-irradiated silk sericin and fibroin in H₂O₂-induced HaCaT Cell
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Ji-Hye Choi Sangmin Lee Hye-Ju Han Jungkee Kwon
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제27권 제1호, 105~112쪽, 전체 8쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2023.01.31
4,000원
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국문 초록
영문 초록
Oxidative stress in skin cells can induce the formation of reactive oxygen species (ROS), which are critical for pathogenic processes such as immunosuppression, inflammation, and skin aging. In this study, we confirmed improvements from gamma-irradiated silk sericin (I-sericin) and gamma-irradiated silk fibroin (I-fibroin) to skin cells damaged by oxidative stress. We found that I-sericin and I-fibroin effectively attenuated oxidative stress-induced ROS generation and decreased oxidative stress-induced inflammatory factors COX-2, iNOS, tumor necrosis factor-α, and interleukin-1β compared to the use of non-irradiated sericin or fibroin. I-sericin and Ifibroin effects were balanced by competition with skin regenerative protein factors reacting to oxidative stress. Taken together, our results indicated that, compared to non-irradiated sericin or fibroin, I-sericin, and I-fibroin had anti-oxidation and antiinflammation activity and protective effects against skin cell damage from oxidative stress. Therefore, gamma-irradiation may be useful in the development of cosmetics to maintain skin health.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
FUNDING
ACKNOWLEDGEMENTS
CONFLICTS OF INTEREST
REFERENCES
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