Effects of Red Ginseng on Exercise Capacity and Peripheral Fatigue in Mice

• 발행기관: 물리치료재활과학회
• 저자명: 김대현(Daehyun Kim) 이병관(Byounggwan Lee) 김희진(Heejin Kim) 김미경(Mikyung Kim)
• 간행물 정보: 『Physical Therapy Rehabilitation Science』제10권 제2호, 175~184쪽, 전체 10쪽
• 주제분류: 의약학 > 재활의학
• 파일형태: PDF
• 발행일자: 2021.06.30

영문 초록

Objective: Fatigue can decrease both quality of life and work efficiency. Ginseng is one of the most popular herbal treatments forimproving personal health, with applications in treating fatigue. However, the exact mechanisms of anti-fatigue effects are stillunclear. Thus, we investigated the effect of red ginseng powder (RGP) on exercise capacity and peripheral fatigue using bothbehavioral and molecular experiments in mice. Design: Four-groups behavioral and molecular experiment. Methods: Male 6-weeks-old ICR mice were treated with distilled water, 100, and 200 mg/kg RGP for 5 days via oraladministration. The exercise capacity of each animal group was measured by locomotor activity, rota-rod, hanging wire, and coldswimming tests. Additionally, after performing the treadmill to induce fatigue, lactate expression and molecular experiments were investigated using mice gastrocnemius. Results: Mice treated with RGP exhibited increased exercise capacity in the behavioral tests. Additionally, RGP induced a dose-dependent decrease in lactate levels after high-intensity exercise, and Monocarboxylate transporter (MCT) 4 expressionincreased in groups treated with RGP. However, there was no significant change in MCT1. Conclusions: These results suggest that RGP exerts several anti-fatigue properties by lower lactate and improved exercisecapacity. Increased MCT4 expression may also affect lactate transport. Thus, this study suggests that the anti-fatigue properties ofRGP might be associated with MCT4 activity.

목차

Introduction

Materials and methods

RESULT

Discussion

Conflict of interest

Acknowledgments

Reference

키워드

Red ginseng Fatigue Monocarboxylate transporter Lactate Exercise capacity