운동학습이 소뇌손상 후 운동능력 및 신경연접 가소성에 미치는 영향

• 영문명: Effects of Motor Learning on Motor Function and Synaptic Plasticity of Cerebellar Injuries
• 발행기관: 한국보건기초의학회
• 저자명: 김기도(Kim, Gi-Do)
• 간행물 정보: 『한국보건기초의학회지』제13권 제2호, 106~111쪽, 전체 6쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2020.12.31

영문 초록

The purpose of this study was to investigate the effects of motor learning on motor function and synaptic plasticity in rats with cerebellar injuries caused by harmaline. The test subjects were divided into three groups, with 15 rats assigned to each group. Group I was a normal control group (induced by saline); Group II was a experimental control group (cerebellar injuries caused by harmaline); Group III was the group that received motor learning after being cerebellar injured by harmaline. In the motor function test, the outcome of group II was significantly lower than that of group III (p<0.001). In the histological findings, the dendrites and nuclei of the cerebellar neurons of the experimental groups were severely damaged. While group III showed a decrease in degeneration of the cerebellar neurons in comparison. The immunohistochemistric response of synaptophysin in the cerebellar cortex was lower in the experimental groups than group I. However group III’s expression of synaptophysin was higher than group II. In electron microscopy findings, the experimental groups showed degeneration of the Purkinje cell. These result suggest that improved motor function by motor learning, after harmaline induced cerebellar injuries, is associated with dynamically altered expression of synaptophysin in the cerebellar cortex and that it is related with synaptic plasticity.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

CONCLUSION

키워드

Cerebellar Excitotoxicity Motor function Motor learning Synaptic plasticity